Tg(Myh6/tetO-Myl4)12Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-Myl4)12Rbns
• Name: transgene insertion 12, Jeffrey Robbins
• MGI ID: MGI:3757952
• Synonyms: MHCmin^TetO-ELC1a
• Transgene: Tg(Myh6/tetO-Myl4)12Rbns Location: unknown
• Alliance: Tg(Myh6/tetO-Myl4)12Rbns page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: This transgene contains the atrium specific form of Myl4 under transcriptional control of a minimally active mouse alpha myosin heavy chain (Myh6) promoter fused to seven copies of the tetracycline-responsive promoter element (tetO). To make the Myh6 promoter minimally active, three GATA sites and two thyroid-like response elements are ablated. When bred with transgenic mice expressing a tetracycline transactivator or reverse transactivator protein, cardiac-specific expression of Myl4 can be controlled by withdrawal or administration of a tetracycline analog. (J:125131)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:125131 Sanbe A, et al., Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res. 2003 Apr 4;92(6):609-16
• All: 1 reference(s)