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Arhgef9tm1.1Betz
Targeted Allele Detail
Nomenclature
Symbol: Arhgef9tm1.1Betz
Name: CDC42 guanine nucleotide exchange factor (GEF) 9; targeted mutation 1.1, Heinrich Betz
MGI ID: MGI:3757650
Synonyms: Collybistin knock-out
Gene: Arhgef9  Location: ChrX:95048935-95196856 bp, - strand  Genetic Position: ChrX, 41.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124926
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsTransfection of ES cells with a cre construct was used to remove exon 5 along with an inserted neo cassette. Exon 5 encodes part of the catalytic RhoGEF domain. Its deletion and resulting frameshift are predicted to destroy the function of the protein and eliminate the entire C-terminus. The absence of full length and truncated protein products was confirmed by western blot on brain homogenates using either a monoclonal specific for the N-terminus or polyclonal antibody against Arhgef9. (J:124926)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef9 Mutation:  4 strains or lines available
References
Original:  J:124926 Papadopoulos T, et al., Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. EMBO J. 2007 Sep 5;26(17):3888-99
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory