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Targeted Allele Detail
Symbol: Ntng2tm1Ito
Name: netrin G2; targeted mutation 1, Shigeyoshi Itohara
MGI ID: MGI:3757587
Synonyms: Ntng2 KO
Gene: Ntng2  Location: Chr2:29194541-29253005 bp, - strand  Genetic Position: Chr2, 19.57 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:124961
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP-flanked neomycin resistance cassette replaced part of the upstream UTR and coding region of this gene. Mice were crossed with Cre recombinase transgenic mice to remove the neo cassette. Northern blot and immunohistochemical analysis on brains of homozygous mice confirmed lack of expression of this gene with no compensatory increases in expression of the related Ntng1 gene. (J:124961)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntng2 Mutation:  9 strains or lines available
Original:  J:124961 Nishimura-Akiyoshi S, et al., Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14801-6
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
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