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Ntng1tm1Ito
Targeted Allele Detail
Nomenclature
Symbol: Ntng1tm1Ito
Name: netrin G1; targeted mutation 1, Shigeyoshi Itohara
MGI ID: MGI:3757573
Synonyms: Ntng1 KO, Ntng1tm1(lacZ)Ito
Gene: Ntng1  Location: Chr3:109780040-110144011 bp, - strand  Genetic Position: Chr3, 48.47 cM, cytoband G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124961
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA N-lacZ reporter gene and a loxP-flanked neomycin resistance cassette was inserted in frame to the initation codon of this gene. Mice were crossed with Cre recombinase transgenic mice to remove the resistance cassette. Northern blot and immunohistochemical analysis on brains of homozygous mice confirmed lack of expression of this gene with no compensatory increases in expression of the related Ntng2 gene. (J:124961)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntng1 Mutation:  5 strains or lines available
References
Original:  J:124961 Nishimura-Akiyoshi S, et al., Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14801-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory