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Atf6tm1.1Rjk
Targeted Allele Detail
Nomenclature
Symbol: Atf6tm1.1Rjk
Name: activating transcription factor 6; targeted mutation 1.1, Randal J Kaufman
MGI ID: MGI:3723526
Synonyms: Atf6alpha-
Gene: Atf6  Location: Chr1:170704674-170867771 bp, - strand  Genetic Position: Chr1, 76.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124971
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 was deleted by Cre-mediated recombination to create a truncated protein product of 72 amino acids that lacks any functional elements of the protein. This allele also contains an FRT flanked neo cassette upstream of the deleted exon 4. The absence of protein was confirmed by western blot analysis on mouse embryonic fibroblast cells. Removal of the neo cassette has no effect on the phenotype. (J:124971)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atf6 Mutation:  9 strains or lines available
References
Original:  J:124971 Wu J, et al., ATF6alpha Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress. Dev Cell. 2007 Sep;13(3):351-64
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory