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Transgene Detail
Symbol: Tg(Tcra1H3.1,Tcrb1H3.1)1Vire
Name: transgene insertion 1, Christophe Viret
MGI ID: MGI:3722813
Synonyms: 1H3.1 TCR Tg
Transgene: Tg(Tcra1H3.1,Tcrb1H3.1)1Vire  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Tcra1H3.1,Tcrb1H3.1)1Vire expresses 2 genes
Mutation detailsTo generate the I-Ab-restricted CD4+ 1H3.1 T cell hybridoma, a peptide corresponding to residues 52-68 of the a-chain of the I-E MHC class II molecule (Ea52-68) was injected into C57BL/6 mice. T cells expressing the T cell receptor (TCR) combination (Va1-Ja21 and Vb6-Db2.1-Jb2.6) were selected. These TCR sequences were cloned into TCR expression cassettes and the resulting constructs were co-microinjected into (C57BL/6 x SJL)F2 oocytes. Mature T cells from 1H3.1 TCR Tg mice (Va1Vb6) are skewed toward expression of the CD4 coreceptor. A subset of TCRhigh CD8+ T cells (5-10%) is found in the periphery. (J:124574)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:124574 Viret C, et al., Functional and phenotypic evidence for presentation of E alpha 52-68 structurally related self-peptide(s) in I-E alpha-deficient mice. J Immunol. 2000 May 1;164(9):4627-34
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory