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Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn
Transgene Detail
Summary
Symbol: Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn
Name: transgene insertion L118-1, Frank Carbone
MGI ID: MGI:3722258
Synonyms: gBT-I, (gB)T-I.1, gBT-I.1
Transgene: Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn  Location: unknown  
Alliance: Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn page
Transgene
origin
Strain of Origin:  (C57BL/6 x bm1)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn expresses 2 genes
 
Mutation detailsRearranged Tcra and Tcrb derived from HSV-1 glycoprotein B specific CTL clone HSV2.3 were placed under the control of a 2 kb fragment of the H-2Kb and a 700 bp fragment including the Igh enhancer. The two constructs were coinjected into F1 embryo zygotes resulting in the establishment of two founder lines. In line L118-1 the two constructs appear to have cointegrated at one site. After backcrossing to C57BL/6, the mouse line referred to as gBT-I.1 was established. (J:124700, J:124701)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:124700 Mueller SN, et al., Characterization of two TCR transgenic mouse lines specific for herpes simplex virus. Immunol Cell Biol. 2002 Apr;80(2):156-63
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory