Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn
Transgene Detail

Summary

• Symbol: Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn
• Name: transgene insertion L118-1, Frank Carbone
• MGI ID: MGI:3722258
• Synonyms: gBT-I, (gB)T-I.1, gBT-I.1
• Transgene: Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn Location: unknown
• Alliance: Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn page

Transgene origin

• Strain of Origin: (C57BL/6 x bm1)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraHsv2.3,TcrbHsv2.3)L118-1Cbn expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Rearranged Tcra and Tcrb derived from HSV-1 glycoprotein B specific CTL clone HSV2.3 were placed under the control of a 2 kb fragment of the H-2K^b and a 700 bp fragment including the Igh enhancer. The two constructs were coinjected into F1 embryo zygotes resulting in the establishment of two founder lines. In line L118-1 the two constructs appear to have cointegrated at one site. After backcrossing to C57BL/6, the mouse line referred to as gBT-I.1 was established. (J:124700, J:124701)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:124700 Mueller SN, et al., Characterization of two TCR transgenic mouse lines specific for herpes simplex virus. Immunol Cell Biol. 2002 Apr;80(2):156-63
• All: 36 reference(s)