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Cd79btm1Gzmn
Targeted Allele Detail
Summary
Symbol: Cd79btm1Gzmn
Name: CD79B antigen; targeted mutation 1, Anna Gazumyan
MGI ID: MGI:3722155
Synonyms: IgbetaAA
Gene: Cd79b  Location: Chr11:106202167-106205388 bp, - strand  Genetic Position: Chr11, 68.89 cM
Alliance: Cd79btm1Gzmn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124400
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsTyrosines 195 and 206 were replaced with alanines. A floxed neo was included in the vector and subsequently removed via cre mediated recombination. (J:124400)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd79b Mutation:  36 strains or lines available
References
Original:  J:124400 Gazumyan A, et al., Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization. J Exp Med. 2006 Jul 10;203(7):1785-94
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory