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Nmur2tm1Rtor
Targeted Allele Detail
Nomenclature
Symbol: Nmur2tm1Rtor
Name: neuromedin U receptor 2; targeted mutation 1, Richard Torres
MGI ID: MGI:3722114
Gene: Nmur2  Location: Chr11:56024987-56041010 bp, - strand  Genetic Position: Chr11, 33.39 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124469
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA LacZ gene and a floxed neomycin selection cassette were inserted in frame after the ATG initiation codon, deleting sequences encoding amino acids 2 through 305. Quantitative RT- PCR on spinal cord tissue failed to detect endogenous gene expression in homozygous mice. LacZ expression was detected in numerous tissues of the homozygous mice. (J:124469)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nmur2 Mutation:  15 strains or lines available
References
Original:  J:124469 Torres R, et al., Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses. Pain. 2007 Aug;130(3):267-78
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory