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Nmur1tm1Rtor
Targeted Allele Detail
Nomenclature
Symbol: Nmur1tm1Rtor
Name: neuromedin U receptor 1; targeted mutation 1, Richard Torres
MGI ID: MGI:3722111
Synonyms: VG221
Gene: Nmur1  Location: Chr1:86386303-86426228 bp, - strand  Genetic Position: Chr1, 43.94 cM, cytoband C5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124469
Parent Cell Line:  F1H4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA LacZ gene and a floxed neomycin selection cassette were inserted in frame after amino acid 17, deleting sequences encoding amino acids 18 through 387. Quantitative RT- PCR on lung tissue failed to detect endogenous gene expression in homozygous mice. LacZ expression was not detected in homozygous mice. (J:102090, J:124469)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nmur1 Mutation:  8 strains or lines available
References
Original:  J:124469 Torres R, et al., Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses. Pain. 2007 Aug;130(3):267-78
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory