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Targeted Allele Detail
Symbol: Angptl1tm1Hung
Name: angiopoietin-like 1; targeted mutation 1, Hung Li
MGI ID: MGI:3721928
Gene: Angptl1  Location: Chr1:156666593-156688648 bp, + strand  Genetic Position: Chr1, 67.75 cM, cytoband G3
Germline Transmission:  Earliest citation of germline transmission: J:124184
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a nuclear LacZ reporter gene and a neomycin selection cassette. No endogenous gene expression was observed in homozygous mice, as determined by RT PCR on several tissues. LacZ staining was observed in the nuclei of cells from the intermuscular fascia of homozygous late stage embryos. (J:124184)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 56 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Angptl1 Mutation:  22 strains or lines available
Original:  J:124184 Lai DM, et al., Angiopoietin-like protein 1 expression is related to intermuscular connective tissue and cartilage development. Dev Dyn. 2007 Sep;236(9):2643-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
The Jackson Laboratory