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C5ar2tm1Gdy
Targeted Allele Detail
Nomenclature
Symbol: C5ar2tm1Gdy
Name: complement component 5a receptor 2; targeted mutation 1, George D Yancopoulos
MGI ID: MGI:3721065
Synonyms: C5L2 KO, VG100
Gene: C5ar2  Location: Chr7:15968512-15978079 bp, - strand  Genetic Position: Chr7, 8.77 cM
Hepatic steatosis in C3tm1Crr/C3tm1Crr and C5ar2tm1Gdy/C5ar2tm1Gdy mice following partial hepatectomy

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102090
Parent Cell Line:  F1H4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsVelocigene technology was used to delete a 1 kb portion of the gene and introduce a lacZ reporter gene. (J:102090)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any C5ar2 Mutation:  15 strains or lines available
References
Original:  J:102090 Valenzuela DM, et al., High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol. 2003 Jun;21(6):652-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory