Tg(Ins2-cre/ERT)1Dam
Transgene Detail

Summary

• Symbol: Tg(Ins2-cre/ERT)1Dam
• Name: transgene insertion 1, Douglas A Melton
• MGI ID: MGI:3720973
• Synonyms: RIP-CreER, Tg(Ins2-cre/Esr1)1Dam
• Transgene: Tg(Ins2-cre/ERT)1Dam Location: unknown
• Alliance: Tg(Ins2-cre/ERT)1Dam page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Ins2-cre/ERT)1Dam expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• The rat insulin promoter was used to drive the expression of tamoxifen-dependent cre recombinase. (J:124161)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ins2 (rat) Summary of all recombinase alleles driven by Ins2. Comparative matrix view of recombinase activities Alliance rat Ins2 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:124161 Dor Y, et al., Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004 May 6;429(6987):41-6
• All: 55 reference(s)