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Atf2tm2Nicj
Targeted Allele Detail
Nomenclature
Symbol: Atf2tm2Nicj
Name: activating transcription factor 2; targeted mutation 2, Nic Jones
MGI ID: MGI:3720851
Synonyms: Atf2AA
Gene: Atf2  Location: Chr2:73816509-73892639 bp, - strand  Genetic Position: Chr2, 43.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123909
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Nucleotide substitutions
 
Mutation detailsA targeting vector was designed to mutate Thr51 and Thr53 into alanines in exon 4 (T51A, T53A). A floxed neo was inserted into intron 3. (J:123909)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atf2 Mutation:  46 strains or lines available
References
Original:  J:123909 Breitwieser W, et al., Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory