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Transgene Detail
Symbol: Tg(Ckm-APPSw)A6Lfa
Name: transgene insertion A6, Frank M LaFerla
MGI ID: MGI:3720796
Synonyms: A6 line, Tg(Ckm-APP*K670N*M671L)A6Lfa, Tg(Ckm-APP*Swe)A6Lfa
Transgene: Tg(Ckm-APPSw)A6Lfa  Location: unknown  
Strain of Origin:  C57BL/6 x SJL
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Ckm-APPSw)A6Lfa expresses 1 gene
Mutation detailsHuman APP cDNA harboring the Swedish double mutation (K670N,M671L) was inserted downstream of the 1.3 kb 5' flanking sequence of the mouse muscle creatine kinase Ckm, upstream of the SV40 polyadenylation signal. The 3.8 kb construct was microinjected into pronuclei of single-cell C57Bl/6 x SJL embryos. Northern blot showed relatively high expression of the transgene in skeletal muscle of line A6 mice, approximately 12 times higher than in Tg(Ckm-APP*K670N*M671L)A2Lfa mice. Western blot showed that transgenic protein expression is ~9 times higher than in mice from line A2. (J:76338)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:76338 Sugarman MC, et al., Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6334-9
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory