Mmp14^tm2Ski
Targeted Allele Detail

Summary

• Symbol: Mmp14^tm2Ski
• Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 2, Motoharu Seiki
• MGI ID: MGI:3720698
• Synonyms: MT1-MMP^lacZ
• Gene: Mmp14 Location: Chr14:54669055-54679913 bp, + strand Genetic Position: Chr14, 27.79 cM
• Alliance: Mmp14^tm2Ski page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124052
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• The NLS-lacZ cassette replaced exons 1-5, which encode the pro- and catalytic domains. (J:124052)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Mmp14 Mutation: 43 strains or lines available

References

• Original: J:124052 Yana I, et al., Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells. J Cell Sci. 2007 May 1;120(Pt 9):1607-14
• All: 10 reference(s)