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Transgene Detail
Symbol: Tg(DMD-APP*)7Neve
Name: transgene insertion 7, Rachel L Neve
MGI ID: MGI:3720652
Synonyms: APP-C100, BetaAPP-C104
Transgene: Tg(DMD-APP*)7Neve  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(DMD-APP*)7Neve expresses 1 gene
Mutation detailsA fragment consisting composed of the sequence ot the terminal 100 amino acids of the beta-amyloid precursor protein (APP) gene (C104, referred to as C100 in J:100978 which states that the transgene contains the terminal 100 amino acids of APP) was inserted into a plasmid encoding the neural-specific dystrophin (DMD) promoter. The vector also contained the SV40 early splice and polyadenylation sequences. Several founder lines were identified, but line 7 was the most extensively characterized line. RT-PCR of tissues from 6-month old mice revealed predominant expression in the brain (>10-fold higher than in any other tissue where low level-transcription was detected). (J:100978, J:105050)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:105050 Kammesheidt A, et al., Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10857-61
All:  2 reference(s)

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MGI 6.07
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