Aicda^tm172Mnz
Targeted Allele Detail

Summary

• Symbol: Aicda^tm172Mnz
• Name: activation-induced cytidine deaminase; targeted mutation 172, Michel C Nussenzweig
• MGI ID: MGI:3720569
• Synonyms: AID^F, Flag AID
• Gene: Aicda Location: Chr6:122530768-122541139 bp, + strand Genetic Position: Chr6, 57.65 cM, cytoband F2
• Alliance: Aicda^tm172Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167917
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An FRT-flanked selection cassette was inserted between exons 1 and 2, and a tandem FLAG and hemagglutinin (HA) tag was inserted at the start site in exon 1. Flp-mediated recombination removed the neo cassette. (J:167917)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aicda Mutation: 55 strains or lines available

References

• Original: J:167917 Pavri R, et al., Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell. 2010 Oct 1;143(1):122-33
• All: 2 reference(s)