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Transgene Detail
Symbol: Tg(Igk-Aicda)14Mnz
Name: transgene insertion 14, Michel C Nussenzweig
MGI ID: MGI:3720492
Synonyms: IgkAID, VkAID tg
Transgene: Tg(Igk-Aicda)14Mnz  Location: unknown  
Strain of Origin:  C57BL/6 x CBA
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Igk-Aicda)14Mnz expresses 1 gene
Mutation detailsThe coding sequence for the Aicda (activation-induced cytidine deaminase) gene is driven by the mouse immunoglobulin kappa light chain promoter (Igk) in this transgene. The construct was injected into C57BL/6 x (C57BL/6 x CBA) embryos. Founder line number 14 was generated. (J:154731)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:154731 Robbiani DF, et al., AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell. 2009 Nov 25;36(4):631-41
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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