Dnmt3l^tm2Bes
Targeted Allele Detail

Summary

• Symbol: Dnmt3l^tm2Bes
• Name: DNA methyltransferase 3-like; targeted mutation 2, Timothy H Bestor
• MGI ID: MGI:3720376
• Synonyms: Dnmt3l^Tag
• Gene: Dnmt3l Location: Chr10:77878121-77899456 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Dnmt3l^tm2Bes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123743
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A targeting vector was used to insert an N-terminal His6-FLAG epitope tag after the first four amino acids of the locus. A floxed pgk-neo included in the vector was subsequently removed via transient cre expression. (J:123743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt3l Mutation: 48 strains or lines available

References

• Original: J:123743 Ooi SK, et al., DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature. 2007 Aug 9;448(7154):714-7
• All: 1 reference(s)