Mapt^tm1Aha
Targeted Allele Detail

Summary

• Symbol: Mapt^tm1Aha
• Name: microtubule-associated protein tau; targeted mutation 1, Akihiro Harada
• MGI ID: MGI:3720198
• Synonyms: tau^-
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm1Aha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123734
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An frt-flanked pgk-neo was inserted to replace exon 1 in reverse orientation. Western blot confirmed absence of transcript in mutant brain samples. (J:123734)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 428 strains or lines available

References

• Original: J:123734 Fujio K, et al., 14-3-3 proteins and protein phosphatases are not reduced in tau-deficient mice. Neuroreport. 2007 Jul 2;18(10):1049-52
• All: 1 reference(s)