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QTL Variant Detail
QTL variant: ImacqLP/J
Name: isoflurane minimum alveolar concentration QTL; LP/J
MGI ID: MGI:3720165
QTL: Imacq  Location: unknown  Genetic Position: Chr7, Syntenic
Strain of Specimen:  LP/J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased isoflurane minimum alveolar concentration compared to C57BL/6J. (J:123468)
View phenotypes and curated references for all genotypes (concatenated display).

Mapping and Phenotype information for this QTL, its variants and associated markers


Linkage analysis was performed on 90 animals from a C57BL/6J x (C57BL/6J x LP/J)F1 backcross to identify QTLs associated with isoflurane minimum alveolar concentration (MAC). A panel of 65 polymorphic markers was used for genome scan. Parental strain LP/J displays higher isoflurane MAC compared to parental strain C57BL/6J. The highest linkage was detected at 15 cM on mouse Chromosome 7 near D7Mi246 (LOD=1.7), corresponding to 30 Mb. C57BL/6J-derived alleles confer increased isoflurane MAC at this locus. SNP analysis of 19 inbred strains confirmed association of isoflurane MAC with the proximal chromosome 7 QTL. This locus is named Imacq (isoflurane minimum alveolar concentration QTL). Previously identified QTL mapping to chromosome 7 include Lorp1 (40 cM) and Etan1 (29 cM).

Original:  J:123468 Cascio M, et al., Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration. Anesth Analg. 2007 Aug;105(2):381-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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