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Tg(Thy1-MAPT)1Vln
Transgene Detail
Summary
Symbol: Tg(Thy1-MAPT)1Vln
Name: transgene insertion 1, Fred Van Leuven
MGI ID: MGI:3720113
Synonyms: htau40-1, tau-4R/2N, thy-1.1-tau
Transgene: Tg(Thy1-MAPT)1Vln  Location: unknown  
Alliance: Tg(Thy1-MAPT)1Vln page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-MAPT)1Vln expresses 1 gene
 
Mutation detailsHuman MAPT cDNA encoding the longest tau isoform of 441 amino acids (called tau40) containing four repeats, with 2 N-terminal inserts was inserted into a murine Thy1 expression vector. Founder line 1 was established by breeding with FVB/N females. Expression of human tau (MAPT) protein exclusively in brain and spinal cord was detected by Western blotting. (J:100972)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:100972 Spittaels K, et al., Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. Am J Pathol. 1999 Dec;155(6):2153-65
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory