Igh^tm2Mbu
Targeted Allele Detail

Summary

• Symbol: Igh^tm2Mbu
• Name: immunoglobulin heavy chain complex; targeted mutation 2, Meinrad Busslinger
• MGI ID: MGI:3719559
• Synonyms: Igh^GFP
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113322
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter)
• Mutations: Deletion, Insertion
• Igh^tm2Mbu involves 1 genes/genome features (Igh) View all
• Igh^tm2Mbu expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD2 (914)

  Cd2	(MGI:88320)

  human

  PAX5 (5079)

  Pax5	(MGI:97489)

• Mutation details: A vector containing human PAX5 cDNA interrupted by a floxed green fluorescent protein cDNA and a stop cassette, with the 3' end of PAX5 linked to human CD2 cDNA by an IRES, replaced Jh1-4 and DQ52 in these mutants. (J:113322)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 47 strains or lines available

References

• Original: J:113322 Delogu A, et al., Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity. 2006 Mar;24(3):269-81
• All: 2 reference(s)