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Aqp9tm1Nlsn
Targeted Allele Detail
Nomenclature
Symbol: Aqp9tm1Nlsn
Name: aquaporin 9; targeted mutation 1, Soren Nielsen
MGI ID: MGI:3719452
Synonyms: Aqp9-
Gene: Aqp9  Location: Chr9:71017941-71075170 bp, - strand  Genetic Position: Chr9, 39.85 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123742
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced 55 nucleotides in exon 2. The insertion was predicted to result in correct translation of the initial 47 amino acids followed by 100 random amino acids and a stop codon. RT-PCR confirmed correct integration of the mutation. An aberrantly spliced transcript was detected, where exon 1 was fused to exon 3, however, the production of protein from this transcript is unlikely. (J:123742)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aqp9 Mutation:  18 strains or lines available
References
Original:  J:123742 Rojek AM, et al., Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3609-14
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory