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Targeted Allele Detail
Symbol: Bsxtm1Aoh
Name: brain specific homeobox; targeted mutation 1, Akihira Ohtoshi
MGI ID: MGI:3719242
Synonyms: BsxdeltaHD
Gene: Bsx  Location: Chr9:40874127-40877972 bp, + strand  Genetic Position: Chr9, 21.65 cM
Germline Transmission:  Earliest citation of germline transmission: J:123638
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA targeting vector containing a floxed neo cassette was inserted by homologous recombination in ES cells and subsequently removed by Cre mediated recombination upon tranmission from male chimeric mice, resulting in the deletion of the homeodomain. Targeting took place in ES cells that contain the Tg(Prm-cre)70Og transgene, which expresses Cre recombinase in male germ cells. Absence of endogenous transcript was confirmed by RT-PCR. (J:123638)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bsx Mutation:  11 strains or lines available
Original:  J:123638 McArthur T, et al., A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing. Mol Cell Biol. 2007 Jul;27(14):5120-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory