Tg(KRT5-Tert)7664Blas
Transgene Detail
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Symbol: |
Tg(KRT5-Tert)7664Blas |
Name: |
transgene insertion 7664, Maria A Blasco |
MGI ID: |
MGI:3719158 |
Synonyms: |
K5-mTERT (T8) |
Transgene: |
Tg(KRT5-Tert)7664Blas Location: unknown
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Alliance: |
Tg(KRT5-Tert)7664Blas page
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Strain of Origin: |
C57BL/6 x DBA/2
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(KRT5-Tert)7664Blas expresses
1 gene
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Tg(KRT5-Tert)7664Blas expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
cattle |
KRT5 (281268) |
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Mutation details: The transgenic construct contained full length murine Tert cDNA adjoined to the bovine KRT5 regulatory region, active in basal keratinocytes. Upregulation of telomerase activity was observed in stratified epithelia of uterus, trachea, and skin tissue obtained from transgenic mice.
(J:69757)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:69757 Gonzalez-Suarez E, et al., Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 2001 Jun 1;20(11):2619-30 |
All: |
3 reference(s) |
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