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Foxp3tm1Kuch
Targeted Allele Detail
Nomenclature
Symbol: Foxp3tm1Kuch
Name: forkhead box P3; targeted mutation 1, Vijay K Kuchroo
MGI ID: MGI:3718527
Synonyms: Fox3eGFP, Foxp3eGFP, Foxp3-eGFP, Foxp3-GFP, Foxp3/GFP+, Foxp3gfp.KI, Foxp3-GFP.KI, Foxp3-IRES-GFP
Gene: Foxp3  Location: ChrX:7579676-7595243 bp, + strand  Genetic Position: ChrX, 3.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123469
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA bicistronic enhanced green fluorescent protein reporter (IRES-GFP) was inserted into the locus. EGFP can be used to faithfully track the expression of the endogenous gene. No disruption to Foxp3 gene function or expression is observed. (J:123469)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  46 strains or lines available
References
Original:  J:123469 Bettelli E, et al., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11;441(7090):235-8
All:  142 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/20/2020
MGI 6.16
The Jackson Laboratory