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Cacna1atm1.1(CACNA1A)Ttan
Targeted Allele Detail
Nomenclature
Symbol: Cacna1atm1.1(CACNA1A)Ttan
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 1.1, Tsutomu Tanabe
MGI ID: MGI:3718033
Synonyms: HL28ki(-)
Gene: Cacna1a  Location: Chr8:84338639-84640246 bp, + strand  Genetic Position: Chr8, 40.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123243
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, RMCE-ready)
Mutation:    Insertion
 
Cacna1atm1.1(CACNA1A)Ttan expresses 1 gene
 
Mutation detailsThis allele resulted from the crossing of Cacna1a with mice expressing Flp recombinase in the germline to remove the CAG-hygro. The locus contained the human cDNA with 28 polyglutamine repeats. (J:123243)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacna1a Mutation:  41 strains or lines available
References
Original:  J:123243 Saegusa H, et al., Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells. Mol Cell Neurosci. 2007 Feb;34(2):261-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory