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Targeted Allele Detail
Symbol: Hdac2tm1.2Eno
Name: histone deacetylase 2; targeted mutation 1.2, Eric N Olson
MGI ID: MGI:3717930
Synonyms: Hdac2-
Gene: Hdac2  Location: Chr10:36974544-37001889 bp, + strand  Genetic Position: Chr10, 19.44 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:123173
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/SvEv
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 2-4 were removed via cre mediated recombination. RT-PCR detected a complete absence of mRNA encoding exons 2-4, but the presence of alternatively spliced transcripts downstream of the deletion. Protein expression was not detected from these transcripts. (J:123173)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac2 Mutation:  27 strains or lines available
Original:  J:123173 Montgomery RL, et al., Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev. 2007 Jul 15;21(14):1790-802
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory