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Transgene Detail
Symbol: Tg(KRT14-rtTA)208Jek
Name: transgene insertion 208, Jeffrey E Kudlow
MGI ID: MGI:3717751
Synonyms: K14-rtTA, K14-rtTA(X), K14-X, rtTA(X), X-linked K14-rtTA
Transgene: Tg(KRT14-rtTA)208Jek  Location: unknown  Genetic Position: ChrX, Syntenic
Strain of Origin:  (C57BL/6 x SJL)
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
Mutation detailsThe K14-rtTA transgene contains the 2.3 kb fragment of the human keratin 14 promoter that drives expression of the reverse tetracycline transactivator gene (rtTA), followed by an SV40 polyadenylation sequence. The 4.9 kb transgene was injected into one-cell (C57BL/6 x SJL) mouse zygotes. Mice from founder line 208 found to harbor the transgene on the X chromosome (also called founder line K14-X). Random X inactivation may result in mosaic rtTA expression patterns in female mice. The transgene when combined with mice carrying a gene under the control of a tetracycline-responsive promoter allows doxycycline-inducible gene expression in skin cells. (J:55970, J:96886)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:96886 Foster KW, et al., Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene. 2005 Feb 24;24(9):1491-500
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory