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Transgene Detail
Symbol: Tg(Thy1-APPLon)2Vln
Name: transgene insertion 2, Fred Van Leuven
MGI ID: MGI:3717572
Synonyms: APP/Ld/2, APP/V717I, Tg(Thy1-APP*Lon)2Vln, Tg(Thy1-APP*V642I)2Vln
Transgene: Tg(Thy1-APPLon)2Vln  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-APPLon)2Vln expresses 1 gene
Mutation detailscDNA encoding the human London (V642I) amyloid precursor protein variant (695 isoform) was cloned into the pTSC vector in the mouse Thy1 gene. The linearized minigene was injected into prenuclear embryos from FVB/N females. Human mutant APP protein is expressed in hippocampus, parietal and frontal cortices at 2-5 times the endogenous APP levels, at lower levels in olfactory bulb and thalamus, and at very low levels in the cerebellum. (J:53800)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:53800 Moechars D, et al., Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem. 1999 Mar 5;274(10):6483-92
All:  25 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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