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Tg(Ckm-DGAT2)10Far
Transgene Detail
Nomenclature
Symbol: Tg(Ckm-DGAT2)10Far
Name: transgene insertion 10, Bob Farese
MGI ID: MGI:3717406
Synonyms: MCK-DGAT2
Transgene: Tg(Ckm-DGAT2)10Far  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6NHsd
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ckm-DGAT2)10Far expresses 1 gene
 
Mutation detailsThe targeting construct was designed with 4 kb of the mouse muscle creatine kinase (MCK) promoter sequence placed upstream of a 1.2 kb human acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) cDNA sequence, followed by a 2.2 kb human growth hormone minigene (providing the polyA signal). The transgene was microinjected into C57BL/6NHsd fertilized eggs and the resulting transgenic offspring were bred to C57BL/6NHsd. Founder line 10 mice were established. (J:129495)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:129495 Levin MC, et al., Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1772-81
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory