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QTL Variant Detail
QTL variant: Frct3C57BL/6J
Name: fear conditioning traits 3; C57BL/6J
MGI ID: MGI:3717235
QTL: Frct3  Location: Chr10:122950065-129631127 bp  Genetic Position: Chr10, Syntenic
Strain of Specimen:  C57BL/6J
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Chromosome substitution strains (CCSs) derived from A/J donor chromosomes on a C57BL/6J genetic background were used to map QTLs for conditioned fear response. Animals aged 48 - 80 days were assessed for freezing to context and freezing to tone before foot shock. A total of 485 CCS mice were phenotyped, along with 82 C57BL/6J and 17 A/J. CCS strains for chromosomes 2 and 8 were not available for study. Recipient strain A/J displays increased freezing to context and altered context, as well as increased pre-training freezing compared to recipient strain C57BL/6J. A/J females displayed significantly increased pre-training freezing compared to A/J males.

CCS-7 and CCS-14 displayed significantly lower freezing to context compared to C57BL/6J, indicating A/J-derived QTL(s) on mouse Chromosomes 7 and 14 that decrease this trait relative to C57BL/6J. These loci are named Frct1 (fear conditioning traits 1) and Frct2 (fear conditioning traits 2), respectively.

Significantly higher freezing to tone was observedinCCS-10 and CCS-18 indicating A/J-derived QTL(s) on mouse Chromosomes 10 and 18 that increase this trait relative to C57BL/6J. These loci are named Frct3 and Frct4, respectively. Frct3 accounts for 24% of the genetic variance in freezing to tone. A previously identified QTL named Exq1 mapped to 67.5 cM on chromosome 10 by Zhang et al (2005) in A/JOlaHsd and C57BL/6JOlaHsd mice. Significantly lower freezing to tone was observed in CCS-12. This locus is named Frct5

CCS-3 displayed significantly higher pre-training freezing and suggestive linkage to decreased freezing to tone and context. CCS-1 also displayed significantly higher pre-training freezing. Authors indicate this is a measure of baseline locomotor activity and not related to fear learning.

Original:  J:121951 Ponder CA, et al., Genetic architecture of fear conditioning in chromosome substitution strains: relationship to measures of innate (unlearned) anxiety-like behavior. Mamm Genome. 2007 Apr;18(4):221-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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