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Tg(Thy1-MAPT)22Schd
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-MAPT)22Schd
Name: transgene insertion 22, Katharina Schindowski
MGI ID: MGI:3717232
Synonyms: THY-Tau22
Transgene: Tg(Thy1-MAPT)22Schd  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x CBA
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-MAPT)22Schd expresses 1 gene
 
Mutation detailscDNA of the 412-amino acid 4-repeat isoform of the human MAPT gene was reamplified and modified by PCR-based site directed mutagenesis to introduce a Kozak-sequence and the mutations G272V and P301S (numbering according to longest human isoform). The cDNA was inserted into a Thy1.2 expression vector and the construct was microinjected into a C57BL/6 x CBA background. 10 copies of the transgene are detected in line 22 animals. Western blot analysis shows high levels of MAPT expression in the brains, and low levels in the spinal cords, of transgenic animals from line 22. (J:111982)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:111982 Schindowski K, et al., Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol. 2006 Aug;169(2):599-616
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory