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Sox17tm1Sjm
Targeted Allele Detail
Nomenclature
Symbol: Sox17tm1Sjm
Name: SRY (sex determining region Y)-box 17; targeted mutation 1, Sean J Morrison
MGI ID: MGI:3717118
Synonyms: Sox17GFP
Gene: Sox17  Location: Chr1:4561154-4567577 bp, - strand  Genetic Position: Chr1, 1.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123050
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace the coding region (involving exons 4 and 5) in frame with the Sox17 start codon, with EGFP and an FRT-flanked neomycin resistance cassette. No Sox17 mRNA is detected by RT-PCR. EGFP is expressed in cells that normally express Sox17. (J:123050)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox17 Mutation:  20 strains or lines available
References
Original:  J:123050 Kim I, et al., Sox17 dependence distingushes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell. 2007 Aug 10;130(3):470-83
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory