Psmb11^tm1Smta
Targeted Allele Detail

Summary

• Symbol: Psmb11^tm1Smta
• Name: proteasome (prosome, macropain) subunit, beta type, 11; targeted mutation 1, Shigeo Murata
• MGI ID: MGI:3716870
• Synonyms: beta5t^-
• Gene: Psmb11 Location: Chr14:54862767-54867013 bp, + strand Genetic Position: Chr14, 27.87 cM
• Alliance: Psmb11^tm1Smta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121869
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence was replaced with cDNA encoding the protein Venus, a derivative of GFP, and a neomycin resistance cassette. Absence of endogenous protein was confirmed by immunoblotting of mutant thymus samples. (J:121869)

Expression

In Mice Carrying this Mutation:

4 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Psmb11 Mutation: 10 strains or lines available

References

• Original: J:121869 Murata S, et al., Regulation of CD8+ T cell development by thymus-specific proteasomes. Science. 2007 Jun 1;316(5829):1349-53
• All: 14 reference(s)