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Dntttm1Fwa
Targeted Allele Detail
Nomenclature
Symbol: Dntttm1Fwa
Name: deoxynucleotidyltransferase, terminal; targeted mutation 1, Frederick W Alt
MGI ID: MGI:3715912
Synonyms: TdT-
Gene: Dntt  Location: Chr19:41029275-41059523 bp, + strand  Genetic Position: Chr19, 34.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75921
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector was used to eliminate the Dntt promoter and exon 1 by homologous recombination. Terminal deoxynucleotidyl transferase enzymatic activity or transcripts from the mutant allele are not detected in Dntt-null thymocytes by RNA blotting. (J:75921)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dntt Mutation:  17 strains or lines available
Notes
Analyses were performed only in chimeric mice.
References
Original:  J:75921 Komori T, et al., Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science. 1993 Aug 27;261(5125):1171-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory