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Tg(Thy1-CFP/COX8A)C1Lich
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-CFP/COX8A)C1Lich
Name: transgene insertion C1, Jeff W Lichtman
MGI ID: MGI:3715524
Synonyms: Thy1-CFP-MitoC
Transgene: Tg(Thy1-CFP/COX8A)C1Lich  Location: unknown  
Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation detailsA transgenic construct containing the entire open reading frame of the Cyan Fluorescent Protein (CFP) gene fused in-frame with the mitochondrial targeting sequence of the human cytochrome c oxidase subunit 8A (ubiquitous) gene under the direction of regulatory elements derived from the mouse Thy1 gene was injected into fertilized donor mouse eggs. Regulatory elements are composed of a 6.5 kb fragment obtained from the 5' portion of the Thy1 gene, extending from the promoter to the intron following exon 4. Exon 3 and its flanking introns are absent. The deleted sequences are required for expression in non-neural cells but not in neurons. The remainder of the sequence is required for neuronal expression. Founder line C1, corresponding to the published line C, was subsequently established. (J:122259)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Founder line C1 corresponds to the published line C.
References
Original:  J:122259 Misgeld T, et al., Imaging axonal transport of mitochondria in vivo. Nat Methods. 2007 Jul;4(7):559-561
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory