Kiss1^tm1Coll
Targeted Allele Detail

Nomenclature

Symbol:	Kiss1^tm1Coll
Name:	KiSS-1 metastasis-suppressor; targeted mutation 1, William H Colledge
MGI ID:	MGI:3715520
Synonyms:	Kiss1^tm1Ptl
Gene:	Kiss1  Location: Chr1:133309827-133329722 bp, + strand  Genetic Position: Chr1, 57.91 cM

Reproductive system defects in female Kiss1^tm1Coll/Kiss1^tm1Coll mice.

Show the 2 phenotype image(s) involving this allele.

Mutation origin

Germline Transmission:	Earliest citation of germline transmission: J:122381
Parent Cell Line:	CCB (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A targeting vector was designed to replace both coding exons with an IRES-lacZ-neo cassette. The absence of transcript and protein was confirmed in mutant mice. (J:122381)

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kiss1 Mutation:	4 strains or lines available

References

Original:	J:122381 d'Anglemont de Tassigny X, et al., Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10714-9
All:	7 reference(s)