Kiss1^tm1Coll
Targeted Allele Detail

Nomenclature

• Symbol: Kiss1^tm1Coll
• Name: KiSS-1 metastasis-suppressor; targeted mutation 1, William H Colledge
• MGI ID: MGI:3715520
• Synonyms: Kiss1^tm1Ptl
• Gene: Kiss1 Location: Chr1:133309827-133329722 bp, + strand Genetic Position: Chr1, 57.91 cM

Reproductive system defects in female Kiss1^tm1Coll/Kiss1^tm1Coll mice.

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122381
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace both coding exons with an IRES-lacZ-neo cassette. The absence of transcript and protein was confirmed in mutant mice. (J:122381)

Disease models

Expression

In Structures Affected by this Mutation:

17 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kiss1 Mutation: 15 strains or lines available

References

• Original: J:122381 d'Anglemont de Tassigny X, et al., Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10714-9
• All: 8 reference(s)