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Kiss1tm1Coll
Targeted Allele Detail
Nomenclature
Symbol: Kiss1tm1Coll
Name: KiSS-1 metastasis-suppressor; targeted mutation 1, William H Colledge
MGI ID: MGI:3715520
Synonyms: Kiss1tm1Ptl
Gene: Kiss1  Location: Chr1:133309827-133329722 bp, + strand  Genetic Position: Chr1, 57.91 cM
Reproductive system defects in female Kiss1tm1Coll/Kiss1tm1Coll mice.

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122381
Parent Cell Line:  CCB (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace both coding exons with an IRES-lacZ-neo cassette. The absence of transcript and protein was confirmed in mutant mice. (J:122381)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kiss1 Mutation:  15 strains or lines available
References
Original:  J:122381 d'Anglemont de Tassigny X, et al., Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10714-9
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory