Npnt^tm1Lfr
Targeted Allele Detail

Summary

• Symbol: Npnt^tm1Lfr
• Name: nephronectin; targeted mutation 1, Louis F Reichardt
• MGI ID: MGI:3715210
• Synonyms: Npnt^floxneo
• Gene: Npnt Location: Chr3:132587506-132656052 bp, - strand Genetic Position: Chr3, 61.52 cM
• Alliance: Npnt^tm1Lfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122519
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked by loxP sites. A neo and a third loxP site were inserted downstream of the floxed exon. (J:122519)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npnt Mutation: 43 strains or lines available

References

• Original: J:122519 Linton JM, et al., The ECM protein nephronectin promotes kidney development via integrin {alpha}8{beta}1-mediated stimulation of Gdnf expression. Development. 2007 Jul;134(13):2501-9
• All: 4 reference(s)