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Targeted Allele Detail
Symbol: Septin3tm1Keng
Name: septin 3; targeted mutation 1, Mineko Kengaku
MGI ID: MGI:3715203
Synonyms: Sept3-
Gene: Septin3  Location: Chr15:82268802-82294574 bp, + strand  Genetic Position: Chr15, 38.56 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:122593
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA partial region of exon 2 and exons 3-5 were replaced with a neomycin resistance cassette flanked by loxP sites. The insertion resulted in the deletion of amino acids 57 to 184. Western blot analysis confirmed absence of protein in brain samples from mutant mice. (J:122593)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Septin3 Mutation:  2 strains or lines available
Original:  J:122593 Fujishima K, et al., Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons. J Neurochem. 2007 Jul;102(1):77-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory