About   Help   FAQ
Gfra1tm2Jmi
Targeted Allele Detail
Nomenclature
Symbol: Gfra1tm2Jmi
Name: glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 2, Jeffrey Milbrandt
MGI ID: MGI:3715156
Synonyms: Gfra1flox, Gfralpha1floxEGFP
Gene: Gfra1  Location: Chr19:58235604-58455909 bp, - strand  Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122607
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfra1 Mutation:  3 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Hirschsprung Disease in mice heterozygous for Gfra1tm1Jmi and Gfra1tm2Jmi and hemizygous for Tg(CAG-cre/Esr1*)5Amc (J:122607)

References
Original:  J:122607 Uesaka T, et al., Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development. 2007 Jun;134(11):2171-81
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory