About   Help   FAQ
Erap1tm1Luc
Targeted Allele Detail
Nomenclature
Symbol: Erap1tm1Luc
Name: endoplasmic reticulum aminopeptidase 1; targeted mutation 1, Luc Van Kaer
MGI ID: MGI:3714520
Synonyms: ERAP1-
Gene: Erap1  Location: Chr13:74639624-74692537 bp, + strand  Genetic Position: Chr13, 40.48 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122479
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace a 600 kb fragment from intron 4 up to the 5' end of exon 6 (which contains the sequence encoding the Zinc-binding motif in the putative active site of the endogenous protein) with a neomycin resistance cassette. RT-PCR verified absence of mRNA in splenocytes and no protein is detected in hepatocytes by immunoblot. (J:122479)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Erap1 Mutation:  39 strains or lines available
References
Original:  J:122479 Yan J, et al., In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J Exp Med. 2006 Mar 20;203(3):647-59
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/10/2017
MGI 6.10
The Jackson Laboratory