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Itga11tm1Dgul
Targeted Allele Detail
Nomenclature
Symbol: Itga11tm1Dgul
Name: integrin alpha 11; targeted mutation 1, Donald Gullberg
MGI ID: MGI:3714472
Synonyms: alpha11-, integrin alpha11-
Gene: Itga11  Location: Chr9:62677855-62783979 bp, + strand  Genetic Position: Chr9, 33.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122349
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA construct containing IRES-lacZ-polyA-loxP-polyA-neo-pgk-loxP was inserted into exon 3. RT-PCR confirmed absence of transcript from exons 3 and beyond in mutants. The neo was subsequently removed by crossing with mice expressing cre recombinase in the germline. (J:122349)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga11 Mutation:  48 strains or lines available
References
Original:  J:122349 Popova SN, et al., Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor. Mol Cell Biol. 2007 Jun;27(12):4306-16
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory