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Chuktm1.1Mpa
Targeted Allele Detail
Nomenclature
Symbol: Chuktm1.1Mpa
Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 1.1, Manolis Pasparakis
MGI ID: MGI:3714161
Gene: Chuk  Location: Chr19:44073335-44107480 bp, - strand  Genetic Position: Chr19, 36.71 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122320
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 6 through 8 were deleted by Cre-mediated recombination to form a null allele. The lack of protein product was confirmed by western blot analysis. (J:122320)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chuk Mutation:  27 strains or lines available
References
Original:  J:122320 Gareus R, et al., Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nat Cell Biol. 2007 Apr;9(4):461-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/17/2017
MGI 6.10
The Jackson Laboratory