Slc32a1^tm1Yyan
Targeted Allele Detail

Summary

• Symbol: Slc32a1^tm1Yyan
• Name: solute carrier family 32 (GABA vesicular transporter), member 1; targeted mutation 1, Yuchio Yanagawa
• MGI ID: MGI:3714155
• Synonyms: VGAT^-
• Gene: Slc32a1 Location: Chr2:158452687-158457668 bp, + strand Genetic Position: Chr2, 78.72 cM, cytoband H1-3
• Alliance: Slc32a1^tm1Yyan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122360
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. Exons 2 and 3 were removed by subsequent cre-mediated recombination. Absence of protein was confirmed by Western blot analysis. (J:122055, J:122360)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc32a1 Mutation: 54 strains or lines available

References

• Original: J:122360 Saito K, Generation and analysis of vesicular GABA transporter knockout mouse. Neuroscience. 2006;:abstract
• All: 6 reference(s)