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Nfixtm1Aes
Targeted Allele Detail
Nomenclature
Symbol: Nfixtm1Aes
Name: nuclear factor I/X; targeted mutation 1, Albrecht E Sippel
MGI ID: MGI:3714028
Synonyms: Nfix-, NfixlacZ
Gene: Nfix  Location: Chr8:84699876-84800344 bp, - strand  Genetic Position: Chr8, 41.02 cM, cytoband C1-C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122250
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace all but the first 4 bp of exon 2 with a lacZ-loxP-neo-loxP cassette. Transient cre expression removed the neo in ES cells. RT-PCR confirmed absence of transcript in mutant brain, liver and lung samples. (J:122250)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfix Mutation:  47 strains or lines available
References
Original:  J:122250 Driller K, et al., Nuclear factor I X deficiency causes brain malformation and severe skeletal defects. Mol Cell Biol. 2007 May;27(10):3855-3867
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory