Fndc3a^{Gt(RRP208)Byg}
Gene trapped Allele Detail

Nomenclature

• Symbol: Fndc3a^{Gt(RRP208)Byg}
• Name: fibronectin type III domain containing 3A; gene trap RRP208, BayGenomics
• MGI ID: MGI:3713800
• Synonyms: Fndc3a^RRP208
• Gene: Fndc3a Location: Chr14:72537946-72710003 bp, - strand Genetic Position: Chr14, 37.62 cM

Mutation origin

• Mutant Cell Line: RRP208
• Germline Transmission: Earliest citation of germline transmission: J:119576
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The pGT0Lxf vector was integrated into intron 3. The integration was predicted to cause loss of full-length protein and result in production of a fusion product composed of the first 57 amino acids fused to the betagalactosidase-neomycin gene. (J:119576)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRP208; (IGTC)	CG671738 ; (MGI Seq Detail)	5' RACE	Chr14:72652018-72709868 bp (-)
  * GRCm38; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;
  Blue line marks approximate position of gene trap insertion;

  27 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fndc3a Mutation: 14 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:119576 Obholz KL, et al., FNDC3A is required for adhesion between spermatids and Sertoli cells. Dev Biol. 2006 Oct 15;298(2):498-513
• All: 2 reference(s)