Irs2^tm1.1With
Targeted Allele Detail

Summary

• Symbol: Irs2^tm1.1With
• Name: insulin receptor substrate 2; targeted mutation 1.1, Dominic J Withers
• MGI ID: MGI:3713784
• Gene: Irs2 Location: Chr8:11034681-11058458 bp, - strand Genetic Position: Chr8, 5.35 cM
• Alliance: Irs2^tm1.1With page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122064
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Cre-mediated recombination was used to remove the open reading frame. (J:97406, J:122064)

Expression

In Mice Carrying this Mutation:	6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs2 Mutation: 35 strains or lines available

References

• Original: J:122064 Neganova I, et al., Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse. Biol Reprod. 2007 Jun;76(6):1045-53
• All: 2 reference(s)